Our research seeks to understand how cells maintain the integrity of their genome. We primarily use the budding yeast Saccharomyces cerevisiae as a model system for studying DNA Mismatch Repair and the pathways that prevent genome rearrangements. We also actively apply insights from our S. cerevisiae studies to understanding how genome stability is dysregulated in many cancers and whether cancer therapies can be developed that target genome instability.
Latest Publications
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination